Abstract
Environmental chemicals comprise a major portion of the human exposome, with some shown to impact the
health of susceptible populations, including pregnant women and developing fetuses. The placenta and cord
blood serve as important biological windows into the maternal and fetal environments. In this article we review
how environmental chemicals (defined here to include man-made chemicals [e.g., flame retardants, pesticides/
herbicides, per- and polyfluoroalkyl substances], toxins, metals, and other xenobiotic compounds) contribute to
the prenatal exposome and highlight future directions to advance this research field. Our findings from a survey
of recent literature indicate the need to better understand the breadth of environmental chemicals that reach the
placenta and cord blood, as well as the linkages between prenatal exposures, mechanisms of toxicity, and
subsequent health outcomes. Research efforts tailored towards addressing these needs will provide a more
comprehensive understanding of how environmental chemicals impact maternal and fetal health.
Faça download completo: Review of the environmental prenatal exposome and its relationship to maternal and fetal health
